The Cases of COVID-19 and Measles Co-Infection in Children

Relevance. The rapid spread of new pathogens inevitably leads to the occurrence of joint circulation with already known infectious agents, leading to the development of mixed infections. The simultaneous circulation of the pandemic coronavirus SARS-CoV-2 with a highly contagious measles virus leads to the development of mixed infections in people who have not been sick or vaccinated against measles. Aims. Review cases of co-infection with measles and COVID-19 in Moscow. Material and methods. A retrospective study of cases of measles and COVID-19 co-infection in three children with a description of the epidemiological and clinical picture of the disease. Results. In all observed children, the manifestation of the disease was typical for measles, the diagnosis of COVID-19 was established based on a laboratory study carried out in a hospital, which gave reason to count. That the infection with SARS-CoV-2 occurred after the infection of children with measles. Conclusions. Different incubation periods can lead to several options for the development of co-infection. The similarity of clinical symptoms at the onset of the disease does not allow excluding a certain infection clinically, without laboratory verification. © Zvereva NN et al.

Multisystem inflammatory syndrome in children associated with new coronavirus infection (COVID-19): clinical and morphological comparisons

Multisystem Inflammatory Syndrome in Children (MIS-C) associated with new coronavirus infection (COVID-19), with signs of Kawasaki disease (KD) and toxic shock syndrome, well-defined diagnostic criteria, is the most severe manifestation of COVID-19 in pediatric patients. MIS-C is analogous to the cytokine storm in children with COVID-19. The article presents a clinical observation of a child with MIS-C with a lethal outcome. Clinical and anamnestic data, the results of laboratory and instrumental research allowed to diagnose MIS-C in a 2-year-old girl with full KD form. Autopsy results, detailed microscopic examination, which revealed systemic vasculitis of small and mediumsized vessels, inflammatory infiltrates in different organs, are presented, clinical and morphological comparisons are made. Детский мультисистемный воспалительный синдром (ДМВС), ассоциированный с новой коронавирусной инфекцией (COVID-19), имеющий признаки болезни Кавасаки (БК) и синдрома токсического шока, четко очерченные диагностические критерии, - самое тяжелое проявление COVID-19 в детском возрасте. ДМВС является аналогом цитокинового шторма при COVID-19 у детей. В статье представлено клиническое наблюдение ребенка с ДМВС с летальным исходом. Клинико-анамнестические данные, результаты лабораторно-инструментальных методов исследования позволили диагностировать ДМВС у девочки 2 лет с полной формой БК. Приведены результаты аутопсии, подробного микроскопического исследования, выявившего системный васкулит сосудов мелкого и среднего калибра, воспалительные инфильтраты в разных органах, проведены клинико-морфологические сопоставления.